Section 14: Immunological Products & Vaccines

Section Description

BNF 14.4

Vaccines and antisera

BNF 14.5

Immunoglobulins

BNF 14.6

International Travel

See BNF for further information, http://www.bnf.org/bnf/bnf/current/2081.htm

BNF 14.4 Vaccines and antisera

Link to Department of Health Immunisation against Infectious Disease: The Green Book

Link to to Department of Health Immunisation Information for Health Professionals and Immunisation Practitioners

Anthrax vaccine

Advice on the use of anthrax vaccine must be obtained from the Centre for Infections, Health Protection Agency (tel. 020 8200 6868).

BCG vaccine
Diagnostic agent

 

Botulism antitoxin

Available from local designated centres, for details see TOXBASE (requires registration) www.toxbase.org. For supplies outside working hours apply to other designated centres and, as a last resort, to Department of Health Duty Officer (Tel (020) 7210 3000).

Cholera vaccine

Immunisation with cholera does not provide complete protection and all travellers to areas where cholera is endemic should take special care with food hygiene.

Diphtheria vaccines

Children under 10 years

DTaP-IPV-Hib (Pediacel®) Diphtheria, tetanus, pertussis (acellular), poliomyelitis (inactivated) and Haemophilus Type B conjugate vaccine (Adsorbed).

Children 3-10 years

DTaP-IPV (Infanrix-IPV®)
Adsorbed diphtheria, tetanus, pertussis (acellular) and poliomyelitis (inactivated).

Children 3-10 years

dTaP-IPV (Repevax®)
Adsorbed diphtheria (low dose), tetanus, pertussis (acellular) and poliomyelitis (inactivated

Children >10 years & adults

dT-IPV (Revaxis®)
Adsorbed diphtheria (low dose), tetanus and inactivated poliomyelitis vaccine.

Diphtheria antitoxin

Treatment, consult product literature
Available from Centre for Infections (Tel (020) 8200 6868)

Haemophilus influenzae
type B

“Catch-up” programme – Infanrix-IPV+Hib®
Children born between 13 March 2003 and 3 September 2005 who have not received a booster dose of haemophilus influenzae type b vaccine at 12 months of age will be offered combined diphtheria, tetanus, pertussis (acellular, component), poliomyelitis (inactivated) and haemophilus type b conjugate vaccine (adsorbed) as part of a ‘catch-up’ programme before school entry; children who have already received their pre-school immunisation without the Hib component will be offered haemophilus influenzae type b vaccine combined with meningococcal group C conjugate vaccine. The ‘catch-up’ dose should be given 3 years after the primary course (this interval can be reduced to a minimum of 1 year if the primary course was delayed).
HiB vaccine (Menitorix®)
See diphtheria vaccines for combination products.

Hepatitis A vaccine

Avaxim® licensed for adults and children over 16 years.
Epaxal® and Havrix Monodose® are licensed for adults and children over 1 year.
Vaqta Paediatric® licensed for children aged 1 - 17 years.

Hepatitis A + hepatitis B vaccine

Twinrix® licensed for adults and children over 1 year.

Hepatitis A + typhoid vaccine

Hepatyrix® licensed for adults and adolescents over 15 years.
ViATIM® licensed for adults and adolescents over 16 years.

Hepatitis B vaccine

Engerix B® and HBvaxPRO®

Hepatitis B + hepatitis A vaccine

Twinrix® licensed for adults and children over 1 year.

Human papilloma virus (HPV) vaccine

Cervarix® for national immunisation programme and Gardasil® outside the standard immunisation programme

Influenza vaccine

 

Measles vaccine
Single vaccine
Combined vaccine

No longer available in the UK.
See MMR vaccine.

Measles. mumps and rubella vaccine


Meningococcal Group C vaccine

 

conjugate  

For childhood immunisation and specific cohorts of patients.

Mumps vaccine
Single vaccine
Combined vaccine

No longer available in the UK.
See MMR vaccine.

Pertussis vaccine
Combined vaccine

See under diphtheria vaccines

Pneumococcal vaccine

polysaccharide

Pneumovax® II Individuals over 5 years at special risk of pneumococcal disease

polysaccharide conjugated

Prevenar® Individuals under 5 years at special risk of pneumococcal disease

Poliomyelitis vaccine

Inactivated

Salk vaccine Not recommended for routine use—combination vaccines are recommended for primary immunisation and for boosters

Live (oral)
Combined vaccine

Sabin vaccine – control of outbreaks only
See diphtheria vaccines

Rabies vaccine

 

Rotavirus vaccine  Vaccination programme for infants from July 2013

Rubella vaccine

Single vaccine
Combined vaccine

No longer available in the UK.
See MMR vaccine.

Smallpox vaccine

Smallpox vaccine is no longer required routinely.

Tetanus vaccine

Single vaccine
Combined vaccine

No longer available in the UK.
See diphtheria vaccines.

Tick-borne encephalitis vaccine

 

Typhoid vaccine

polysaccharide

 

Typhoid + hepatitis A vaccine

See hepatitis A + typhoid vaccine

Varicella–zoster vaccine  (high potency)

Recommended for the prevention of herpes zoster (shingles) in adults who are, or were, 70 years of age on 1 September 2014. 

Varicella–zoster vaccine for immunisation against varicella (chickenpox) in seronegative individuals  Not recommended for routine use in children, but can be given to seronegative healthy children over 1 year who come into close contact with individuals at high risk of severe varicella infections. The Department of Health recommends these vaccines for seronegative healthcare workers who come into direct contact with patients. Those with a history of chickenpox or shingles can be considered immune, but healthcare workers with a negative or uncertain history should be tested. 

Yellow fever vaccine

Available only from designated Yellow Fever Vaccination Centres. Local centre information:
Local Travel Vaccine Flyer

BNF 14.5 Immunoglobulins

Normal immunoglobulin

 

Normal immunogolbulin

Prescribe product by brand name
Vigam® for intravenous use.
Gammaplex® for intravenous use

Specific immunoglobulins

See BNF and contact the Pharmacy Department if a specific immunoglobulin is required. Contact the microbiology department for advice.

Hepatitis B immunoglobulin
Varicella-Zoster immunoglobulin

Available from the:
Virology Department, Heartlands Hospital. Birmingham.
Telephone: 0121 766 6611 (ext 4075)

Anti-D immunoglobulin

Available from the haematology department.

BNF 14.6 International Travel

See Section 14.4 (Vaccines antisera).

WHO advice on international travel and health www.who.int/ith